Though some elements in this story were a bit strong for me, I thought it very well told, with strong narrative drive. The characters display a great deal of personatlity (I really like the developing partnership between Bubbles and Slick). Nice character design all around.
If I have a concern (disregarding content), it's that the text is often squeezed uncomfortably into the word balloons, making it difficult to read. Prescripting might solve this problem, allowing you to judge more accurately the size of word balloon needed.
This has been a very long post. A great deal of work went into it, and I mostly enjoyed it. I eagerly await whatever comes next, whether it's the further adventures of Trish or something entirely new. Solid work!